Project Summary
P9 will perform structural and functional analysis of their established NaPi-IIa interactome to investigate the significance and 3D-structure of selected transporter super-complexes, and to unravel the complexome of human brush-border membranes and whole rodent kidney through quantitative proteomic/biochemical analyses of native and heterologously expressed subsets of interactome constituents with NaPi-IIa, functional investigations of the underlying protein-protein interactions, and structural investigations of the identified super-complexes. Thereby, P9 will gain new insights into phosphate handling in the human kidney and diseases resulting from genetic defects thereof.
