Project Summary
P7 will investigate molecular functions of the two transcription factors (TFs) Foxd2 and Ovol1, identified by NephGen members as mutated in monogenic congenital anomalies of the kidney and urinary tract (CAKUT) and/or associated with adult kidney dysfunction. Molecular roles and expression control of these TFs and their target pathways will be analyzed during kidney morphogenesis and in adult mice using a combination of genetic in vitro models as well as disease modeling in mice. Morphogenesis of normal and disturbed nephron formation in the genetic model systems P7 will be directly observed by time-lapse imaging of kidney organ-cultures ex vivo.
