Project Summary
P15 recently discovered common risk variants in >200 novel genetic loci for complex kidney function traits and diseases in >1 million individuals. P15 will address the continuum of genetic risk from complex to monogenic kidney disease by examining the contribution of rare risk alleles in large population-based and CKD patient studies. P15 will use next-generation sequencing approaches to quantify the presence of monogenic kidney disease mutations in adults with presumed complex kidney disease, with the potential to directly inform clinical decisions. The genome-wide results generated by P15 will represent an important resource for other NephGen projects, in which any candidate gene of interest can be investigated.
