Anna Köttgen

Current Position

Director of the Institute of Genetic Epidemiology, University of Freiburg
Speaker, CRC 1453 (Nephrogenetics)

Academic Education

2005 - 2006	Master of Public Health (M.P.H.), Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
1994 - 2001	Studies of Human Medicine (M.D.), University of Freiburg

Advanced Qualifications

2011	Habilitation, Experimental Medicine, University of Freiburg
2001 - 2003	United States Medical Licensing Examinations, steps I and II CK
2002	Doctoral degree in medicine (Dr. med.), University of Freiburg

Postgraduate Positions

2017 - present	Director, Institute of Genetic Epidemiology, Medical Center - University of Freiburg
2016 - 2020	Heisenberg Professorship for Genetic Epidemiology, University of Freiburg
2016 - present	Co-Director, International Chronic Kidney Disease Genetics (CKDGen) Consortium
2010 - 2015	Emmy Noether Group Leader, Dept. of Medicine IV, University of Freiburg
2009 - present	Professor - Adjunct, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
2009 - present	Study Site Co-Director Freiburg, German Chronic Kidney Disease Study
2008 - 2009	Assistant Scientist, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
2006 - 2008	Postdoctoral Research Fellow, The German Research Foundation, Dept. of Epidemiology, Johns Hopkins University, Baltimore, USA

Link to all publications of Anna Köttgen: PubMed

Publications on CRC 1453 funding

Gruber I, Kollerits B, Forer L, …, Schultheiss UT, Köttgen A, Eckardt KU, Coassin S, Lamina C, Kronenberg F. Lipoprotein(a) concentrations and cardiovascular disease in patients with chronic kidney disease: Results from the German Chronic Kidney Disease study. J Intern Med (2024). Eble J, Köttgen A, Schultheiss UT. Monogenic Kidney Diseases in Adults With Chronic Kidney Disease (CKD). Dtsch Arztebl Int (2024). Li LV, Xiao S, Schlosser P, Scherer N, Wiggenhorn AL, Spaas J, Tung ASH, Karoly ED, Köttgen A, Long JZ. SLC17A1/3 transporters mediate renal excretion of Lac-Phe in mice and humans. Nat Commun (2024). Patil S, Borisov O, Scherer N, Wirth C, Schlosser P, Wuttke M, …, Eckardt KU, Hunte C, Neubauer B, Köttgen A, Köttgen M. The membrane transporter SLC25A48 enables transport of choline into human mitochondria. Kidney Int (2024). Talvard-Balland N, Braun LM, Dixon KO, …, Köttgen A, …, Börries M, …, Becher B, Köhler N, Wertheimer T, Kuchroo VK, Zeiser R. Oncogene induced TIM-3 ligand expression dictates susceptibility to anti-TIM-3 therapy in mice. J Clin Invest (2024). Monteiro-Martins S, Sterenborg RBTM, Borisov O, Scherer N, Cheng Y, Medici M, Köttgen A, Teumer A. New insights into the hypothalamic-pituitary-thyroid axis: a transcriptome- and proteome-wide association study. Eur Thyroid J (2024). Yeo WJ, Surapaneni AL, Hasson DC, Schmidt IM, Sekula P, Köttgen A, …, Vasan RS, Kimmel PL, Coresh J, Grams ME, Schlosser P. Serum and Urine Metabolites and Kidney Function. J Am Soc Nephrol (2024). Steinbrenner I, Schultheiss UT, Bächle H, …, Schlosser P, …, Schaeffner E, Eckardt KU, Köttgen A, Sekula P, GCKD Ivestigators. Associations of Urine and Plasma Metabolites with Kidney Failure and Death in a CKD Cohort. Am J Kidney Dis (2024). Kellner E, Sekula P, Lipovsek J, …, Bamberg F, Büchert M, Reichardt W, Reisert M, Köttgen A. Imaging Markers Derived From MRI-Based Automated Kidney Segmentation—an Analysis of Data From the German National Cohort (NAKO Gesundheitsstudie). Dtsch Ärztebl Int (2024). Schlosser P, Surapaneni AL, Borisov O, …, Köttgen A, Rhee EP, Coresh J, Grams ME, CRIC Study Investigators & CKD Biomarkers Consortium. Association of Integrated Proteomic and Metabolomic Modules with Risk of Kidney Disease Progression. J Am Soc Nephrol (2024). Vlasschaert C, Robinson-Cohen C, Chen J, …, Köttgen A, …, Kestenbaum B, Lanktree MB, Rauh MJ, Harris Jr RC, Bick AG. Clonal hematopoiesis of indeterminate potential is associated with acute kidney injury. Nat Med (2024). Clotet-Freixas S, Zaslaver O, Kotlyar M, …, Sekula P, Steinbrenner I, Köttgen A, …, Jurisica I, Woo M, Scholey JW, Röst H, Konvalinka A. Sex differences in kidney metabolism may reflect sex-dependent outcomes in human diabetic kidney disease. Sci Transl Med (2024). Suzuki K, Hatzikotoulas K, Southam L, …, Wuttke M, …, Köttgen A, …, Rotter JI, Vujkovic M, Voight BF, Morris AP, Zeggini E. Genetic drivers of heterogeneity in type 2 diabetes pathophysiology. Nature (2024). Scholz M, Horn K, Pott J, Wuttke M, Kühnapfel A, …, Köttgen A, Schlosser P, Pattaro C. X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements. Nat Commun (2024). Riedhammer KM, Nguyen TMT, Kosukcu C, Calzada-Wack J, Li Y, …, Schlosser P, …, Wuttke M, …, Bergmann C, …, Antony D, …, Schell C, …, Köttgen A, Arnold S, Ozaltin F, Schmidts M, Hoefele J. Implication of transcription factor FOXD2 dysfunction in syndromic congenital anomalies of the kidney and urinary tract (CAKUT). Kidney Int (2023). Moritz L, Schumann A, Pohl M, Köttgen A, Hannibal L, Ute Spiekerkoetter. A systematic review of metabolomic findings in adult and pediatric renal disease. Clin Biochem (2023). Haug S, Muthusamy S, Li Y, Stewart G, Li X, Treppner M, Köttgen A, Akilesh S. Multi-omic analysis of human kidney tissue identified medulla-specific gene expression patterns. Kidney Int (2023). Kheirkhah A, Schachtl-Riess JF, Lamina C, Di Maio S, Koller A, …, Sekula P, …, Köttgen A, Eckardt KU, Kronenberg F. Meta-GWAS on PCSK9 concentrations reveals associations of novel loci outside the PCSK9 locus in White populations. Atherosclerosis (2023). Grams ME, Coresh J, Matsushita K, Ballew SH, Sang Y, …, Köttgen A, …, Zhang L, Levey AS, Gansevoort RT. Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes: An Individual-Participant Data Meta-Analysis. JAMA (2023). Chen TK, Estrella MM, Appel LJ, Surapaneni AL, Köttgen A, Obeid W, Parikh CR, Grams ME. Associations of Baseline and Longitudinal Serum Uromodulin With Kidney Failure and Mortality: Results From the African American Study of Kidney Disease and Hypertension (AASK) Trial. Am J Kidney Dis (2023). Kiryluk K, Sanchez-Rodriguez E, Zhou XJ. Zanoni F, Liu L, …, Schlosser P, …, Köttgen A, …, Scolari F, Zhang H, Gharavi AG. Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy. Nat Genet (2023). Schlosser P, Scherer N, Grundner-Culemann F, Monteiro-Martins S, Haug S, …, Wuttke M, …, Köttgen M, …, Schmidts M, …, Schultheiss UT, …, Sekula P, Li Y, Köttgen A. Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine. Nat Genet (2023). Wuttke M, König E, Katsara MA, Kirsten H, Farahani SK, …, Günzel D, Köttgen A, Fuchsberger C. Imputation-powered whole-exome analysis identifies genes associated with kidney function and disease in the UK Biobank. Nat Commun (2023). Pfau A, López-Cayuqueo KI, Scherer N, Wuttke M, Wernstedt A, …, Köttgen A, Jentsch TJ, Knauf F. SLC26A1 is a major determinant of sulfate homeostasis in humans. J Clin Invest (2023) Steinbrenner I, Yu Z, Jin J, Schultheiss UT, Kotsis F, …, Wuttke M, …, Chatterjee N, Sekula P, Köttgen A. A polygenic score for reduced kidney function and adverse outcomes in a cohort with chronic kidney disease. Kidney international (2022). Kocylowski MK, Aypek H, Bildl W, Helmstädter M, Trachte P, …, Köttgen A, …, Huber TB, Fakler B, Grahammer F. A slit-diaphragm-associated protein network for dynamic control of renal filtration. Nat Commun (2022). Westermann L, Li Y, Göcmen B, Niedermoser M, Rhein K, …, Köttgen A, Köttgen M, Busch T. Wildtype heterogeneity contributes to clonal variability in genome edited cells. Sci Rep (2022). Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, …, Wuttke M, …, Köttgen A, …, Wood AR, Visscher PM, Hirschhorn JN. A saturated map of common genetic variants associated with human height. Nature (2022). Najafi M, Riedhammer KM, Rad A, Torbati PN, Berutti R, …, Köttgen A, Backofen R, Karimiani EG, Hoefele J, Schmidts M. High detection rate for disease-causing variants in a cohort of 30 Iranian pediatric steroid resistant nephrotic syndrome cases. Front Pediatr (2022). Steinbrenner I, Köttgen A. A polygenic score predicts CKD across ancestries. Nat Rev Nephrol (2022). Olinger E, Schaeffer C, Kidd K, Elhassan EAE, Cheng Y, …, Köttgen A, …, Sayer JA, Rampoldi L, Devuyst O. An intermediate-effect size variant in UMOD confers risk for chronic kidney disease. Proc Natl Acad Sci USA (2022). Kayser N, Zaiser F, Veenstra AC, Wang H, Göcmen B, Eckert P, Franz H, Köttgen A, Walz G, Yakulov TA. Clock genes rescue nphp mutations in zebrafish. Hum Mol Genet (2022). Gorski M, Rasheed H, Teumer A, Thomas LF, Graham SE, .., Köttgen M, …, Köttgen A, Kronenberg F, Heid IM. Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies. Kidney Int (2022). Mahajan A, Spracklen CN, Zhang W, Ng MCY, Petty LE, …, Wuttke M, …, Preissl S, …, Köttgen A, …, Rotter JI, McCarthy MI, Morris AP. Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. Nat Genet (2022). Keshawarz A, Hwang SJ, Lee GY, Yu Z, Yao C, Köttgen A, Levy D. Cardiovascular disease protein biomarkers are associated with kidney function: The Framingham Heart Study. PLoS One (2022). Chen TK, Surapaneni AL, Arking DE, Ballantyne CM, Boerwinkle E, …, Köttgen A, Susztak K, Tin A, Yu B, Grams ME. APOL1 Kidney Risk Variants and Proteomics. Clin J Am Soc Nephrol (2022). Zhang J, Dutta D, Köttgen A, Tin A, Schlosser P, …, Boerwinkle E, Coresh J, Chatterjee N. Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies. Nat Genet (2022). Li Y, Cheng Y, Consolato F, Schiano G, Chong MR, …, Sekula P, Steinbrenner I, Schlosser P, …, Schultheiss UT, …, Wuttke M, …, Devuyst O, Rampoldi L, Köttgen A. Genome-wide studies reveal factors associated with circulating uromodulin and its relations with complex diseases. JCI Insight (2022). KDIGO Conference Participants. Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int (2022). Joseph CB, Mariniello M, Yoshifuji A, Schiano G, Lake J, …, Wuttke M, …, Köttgen A, Hayward C, Devuyst O. Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin. JASN (2022). Schlosser P, Tin A, Matias-Garcia PR, Thio CHL, Joehanes R,, …, Susztak K, Köttgen A, Teumer A. Meta-analyses identify DNA methylation associated with kidney function and damage. Nat Commun (2021). Tin A, Schlosser P, Matias-Garcia PR, Thio CHL, Joehanes R, …, Susztak K, Teumer A, Köttgen A. Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus. Nat Commun (2021). Yu Z, Jin J, Tin A, Köttgen A, Yu B, …, Chatterjee N, Grams ME, Coresh J. Polygenic Risk Scores for Kidney Function and Their Associations with Circulating Proteome, and Incident Kidney Diseases. J Am Soc Nephrol (2021). Tin A, Köttgen A. Mendelian Randomization Analysis as a Tool to Gain Insights into Causes of Diseases: A Primer. J Am Soc Nephrol (2021). Hoefflin R, Harlander S, Abhari BA, Peighambari A, Adlesic M, …, Börries M, Köttgen A, Heikenwalder M, Frew IJ. Therapeutic Effects of Inhibition of Sphingosine-1-Phosphate Signaling in HIF-2α Inhibitor-Resistant Clear Cell Renal Cell Carcinoma. Cancers (2021). Getwan M, Hoppmann A, Schlosser P, Grand K, Song W,…, Lausch E, Köttgen A, Lienkamp SS. Ttc30a affects tubulin modifications in a model for ciliary chondrodysplasia with polycystic kidney disease. Proc Natl Acad Sci USA (2021). Stanzick KJ, Li Y, Schlosser P, Gorski M, Wuttke M, …, Köttgen A, Stark KJ, Heid IM, Winkler TW. Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals. Nat Commun (2021). Matías-García PR. Wilson R, Guo Q, Zaghlool SB, Eales JM, …, Schlosser P, …, Köttgen A, …, Tomaszewski M, Teumer A, Waldenberger M. Plasma Proteomics of Renal Function: A Transethnic Meta-Analysis and Mendelian Randomization Study. J Am Soc Nephrol (2021). Kotsis F, Schultheiss UT, Wuttke M, Schlosser P, Mielke J, …, Sekula P, Köttgen A, GCKD Investigators. Self-Reported Medication Use and Urinary Drug Metabolites in the German Chronic Kidney Disease (GCKD) Study. J Am Soc Nephrol (2021). Cheng Y, Schlosser P, Hertel J, Sekula P, Oefner PJ, …, Schmidts M; …, Thiele I, Li Y, Köttgen A. Rare genetic variants affecting urine metabolite levels link population variation to inborn errors of metabolism. Nat Commun (2021).