Congratulations!
In a highly collaborative effort, NephGen PIs and Associate Members Pascal Schlosser, Anna Köttgen, Matthias Wuttke, Michael Köttgen, Miriam Schmidts, Ulla Schultheiss and Peggy Sekula, in cooperation with multiple national and international researchers, published the study “Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine” in Nature Genetics.
They integrated genetic profiles of 5,000 study participants with their plasma and urine metabolomes, in order to identify and characterize systemic and kidney-specific metabolic processes, and identified 1,299 metabolite-associated genetic loci that contribute to the production, degradation or transport of the implicated metabolites. Associations with 40% of implicated metabolites would have been missed by studying plasma alone.
Check out the paper to read about kidney-specific findings as well as relations to health outcomes: https://rdcu.be/ddNFl
And like and share on Twitter: https://twitter.com/SFB1453_NephGen/status/1665740894325071872
