Collaborative Research Center 1453
NephroGenetics
Kidney disease represents a global public health challenge. Chronic kidney disease alone affects 10-15% of adults and increases the risk for kidney failure, adverse cardiovascular outcomes, and mortality. Despite the high prevalence and the great costs associated with treating kidney diseases, the low number of clinical trials and specific treatments in nephrology attests to a shortage of therapeutic targets. The identification of druggable targets has been hampered by an incomplete understanding of the mechanisms underlying the etiology and progression of kidney diseases. Pharmacological compounds that operate on proteins or pathways connected to a given disease by human genetic evidence are at least twice as likely to gain approval, compared to those without genetic support. Therefore, the long-term vision of the CRC 1453 is to use evidence from genetic kidney diseases to identify, characterize, and modify molecules and pathways that represent targets to improve the prevention and treatment of kidney disease.
Seminars
Publications
Smit RAJ, Wade K, Hui Q, …, Wuttke M, …, Timpson NJ, Hirschhorn JN, Sun YV, Berndt SI, Loos RJF. Polygenic prediction of body mass index and obesity through the life course and across ancestries. Nat Med (2025).
Schrecker M, Son Y, Planells-Cases R, Kar S, Vorobeva V, Schulte U, Fakler B, Jentsch TJ, Hite RK. Structural basis of ClC-3 transporter inhibition by TMEM9 and PtdIns(3,5)P2. Nat Struct Mol Biol (2025).
Chatterjee S, Rückert T, Martin I, …, Andrieux G, Cabezas-Wallscheid N, Börries M, Prinz M, Zeiser R. Gut microbiota-derived TMAVA is a modulator of acute CNS-GVHD. J Exp Med (2025).
Schlosser P, Köttgen A. A multiomic resource to interpret genetic associations with kidney function. Kidney Int (2025).
Chaves AFA, de Barros BCSC, Cosenza-Contreras M, …, Pinter N, Schmid M, Santoro ML, Schilling O, Serrano SMT. Signatures of the systemic effects of a snake venom and antivenom: multiomics profiling of the kidney pathology. Mol Cell Proteomics (2025).
Xie W, Franz H, Yakulov TA. Evaluating In-Hospital Arrhythmias in Critically Ill Acute Kidney Injury Patients: Predictive Models, Mortality Risks, and the Efficacy of Antiarrhythmic Drugs. J Clin Med (2025).
Runge S, von Zedtwitz S, Maucher AM, …, Schell C, Boerries M, Strowig T, Andrieux G, Hild B, Rosshart SP. Laboratory mice engrafted with natural gut microbiota possess a wildling-like phenotype. Nat Commun (2025).
Peighambari A, Huang H, Metzger P, Adlesic M, …, Köttgen A, Schell C, …, Zeiser R, Heikenwalder M, Höfflin R, Boerries M, Frew I. Characterisation of an autochthonous mouse ccRCC model of immune checkpoint inhibitor therapy resistance. Sci Rep (2025).
Teng YH, Appiah B, Andrieux G, …, Hofmann AS, Ku M, Beyes S, Boerries M, Hecht A. TGF-β signaling redirects Sox11 gene regulatory activity to promote partial EMT and collective invasion of oncogenically transformed intestinal organoids. Oncogenesis (2025).
Konwar S, Schroda S, Rogg M, …, Grosse R, Schell C, Vidal S, Liu X, Gorzelanny C, Tschongov T, Häffner K. Thrombospondin-1 inhibits alternative complement pathway activation in antineutrophil cytoplasmic antibody-associated vasculitis. J Clin Invest (2025).
More Publications
Contact
